TRT Plus

• Dose Titration - Ramping and tapering plans can now be set for any compound. Define a target, timeframe, and adjustment frequency — the app builds a dated week-by-week plan and automatically adjusts on schedule. Re-open the plan at any time to see completed, current, and upcoming steps. Community requested. • Today Progress Bar - A live dose tracker showing how many compounds have been taken and how many remain, with a progress bar that fills as you go. • Engine Schematic - The My Biomarkers knowledge base now includes a visual map of the full scoring engine, showing how each biomarker feeds into and relates to the others across the cardiovascular, hormonal, and metabolic systems. • Compound Detail Strip - A live inventory countdown shows days remaining with color-coded urgency, and active Ramping or Tapering plans are summarized at a glance at the bottom of each compound card. • Nebido Support - Testosterone Undecanoate is now fully supported. Long-interval dosing from Every 3 to Every 16 Weeks is available exclusively when Nebido is selected. The fluctuation chart and Testimator both use a calibrated depot absorption model — levels rise to peak at day 7 post-injection and the Testimator timeline expands to 14 weeks to give a meaningful view of the full dosing cycle. A 5 mL syringe is set to hold the 4 mL standard volume. Community requested. • Titration Forecasting - Dose titration schedules are now visible on compound charts, showing your planned ramping or tapering steps, target achievement date, and elimination timeline in one integrated view. • HDL & LDL Markers - LDL Cholesterol replaces HDL as the secondary cardiovascular marker, displayed automatically when superior marker ApoB is not present in your bloodwork. • Compound Database Updates - Dutasteride added to Advanced, BPC + TB-500 and CJC + Ipamorelin blend entries added to Peptides. Community requested.

• Testosterone Cream - Topical testosterone is now fully supported in My Protocol, represented as a Topi-CLICK® dispenser with +/- click buttons to adjust. • Peptide Reconstitution Calculator - When adding a peptide, you're guided through setting concentration. Enter your vial's dry powder amount and bac water volume calculates automatically. You can override in any direction — adjust bac water to recalculate concentration, or enter a target concentration to recalculate water volume. Unusual concentrations are flagged. • The Testimator - Significant redesign to simplify data input. Baseline Protocol is now pulled from your Testosterone details in My Protocol, Total Testosterone anchors the model from My Biomarkers, and Blood Test Timing has been added to reflect whether blood was drawn at peak or trough. • My Bloodwork - A dedicated hub to order the TRT Plus panel, upload results, generate your AI report, and book a consult. Each step is clearly labelled to guide you through the full bloodwork cycle. • High / Low Indicators - Each biomarker card now shows an H or L when a result falls outside TRT Plus optimised reference ranges. • Transdermal Pharmacokinetic Models - Cream compounds use two dedicated models for transdermal delivery. Absorbed amount is calculated via a Michaelis-Menten saturation model using site-specific parameters. The Compound Plotter and PTF calculation use a Bateman bi-exponential function, producing an accurate rise-to-peak curve rather than the instantaneous depot model used for injectables. • Testosterone Cream & Injectable Equivalent Converter - Select a weekly amount and application site to see your injectable equivalent in mg/W, using a Michaelis-Menten model with site-specific absorption ceilings and half-saturation points. • Protocol Validation - Ensures your compounds and amounts in My Protocol reflect what you were actually taking at the time of bloodwork, before being sent to AI for interpretation. • Chart Aesthetic Update - Charts and score gauges refined to match the glassmorphic feel of the app. Onboarding hints added. • Order Bloodwork - Choose between Essential and Comprehensive panels, order via our pathology partners, or use the combined marker list for private ordering or to show your doctor. • Compound Slots - My Protocol now supports up to 10 compounds, doubled from 5. • Injection Frequency Science - The Frequency knowledge base now includes a clinical breakdown of why injection interval matters. Steady-state accumulation theory and peak-to-trough data compare protocols from fortnightly to daily. Four cited studies are linked, including Nankin 1987 and the 2025 Walia clinical review. • E2 & DHT: The Paracrine Picture - New knowledge base section on E2 and DHT. Both are produced locally inside cells — a paracrine process — which is why plasma levels tell only part of the story, and why AIs and 5ARIs act systemically rather than at the symptom site. • GH Secretagogues & IGF-1 Bloodwork Timing - Three new sections covering how GH secretagogues work, the liver's 4–8 hour GH-to-IGF-1 conversion window, and a compound-by-compound bloodwork timing guide. • HDL & eGFR Markers - HDL Cholesterol and eGFR are reintroduced as secondary cardiovascular and kidney markers, shown automatically when ApoB or Cystatin C are not detected in your bloodwork. • Cardio-Metabolic Cascade - The formula behind your personalised testosterone reference range is now documented, showing how your cardiovascular and metabolic markers cascade into your scoring thresholds.